{"id":13797,"date":"2023-10-09T16:09:10","date_gmt":"2023-10-09T08:09:10","guid":{"rendered":"https:\/\/research.utm.my\/ihumen\/?p=13797"},"modified":"2024-10-29T13:01:03","modified_gmt":"2024-10-29T05:01:03","slug":"chitoe-graft","status":"publish","type":"post","link":"https:\/\/research.utm.my\/ihumen\/chitoe-graft\/","title":{"rendered":"ChitoE Graft"},"content":{"rendered":"<div class=\"et_d4_element et_pb_section et_pb_section_0  et_pb_css_mix_blend_mode et_section_regular et_block_section\" >\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_d4_element et_pb_row et_pb_row_0  et_pb_css_mix_blend_mode et_block_row\">\n\t\t\t\t<div class=\"et_d4_element et_pb_column_4_4 et_pb_column et_pb_column_0  et_pb_css_mix_blend_mode et-last-child et_block_column\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_text et_pb_text_0  et_pb_text_align_left et_pb_bg_layout_light\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_text_inner\"><p style=\"text-align: justify\"><span class=\"OYPEnA text-decoration-none text-strikethrough-none\">A newly biocompatible, anti-thrombogenic<\/span> <span class=\"OYPEnA text-decoration-none text-strikethrough-none\">vascular membrane<\/span><\/p>\n<div>\n<p style=\"text-align: justify\">Cardiovascular diseases have been the leading cause of mortality, according to the World Health Organization (WHO) for the past few years. In 2021, specifically in Malaysia the Department of Statistics recorded that 17% of Malaysians died due to ischemic heart disease as the topmost ranking, Followed by pneumonia (11.4%), cerebrovascular diseases (8.3%) and transport accidents (2.9%).<\/p>\n<div>\n<p style=\"text-align: justify\">Most cardiovascular diseases require vascular reconstructive surgery to remove affected tissue lesions. Several vascular membranes\/grafts are commercially available to replace defective tissues in vascular reconstructive surgery. However, synthetic commercialized vascular membranes\/grafts known as GORE-TEX\u00ae (made of polytetrafluoroethylene (PTFE)) and Dacron\u00ae (made of polyethene terephthalate (PET)) are not biodegradable.<\/p>\n<p style=\"text-align: justify\">They are reported with post-complication of thrombotic formation following the implantation procedure. Although myriad tissue engineering approaches have been considered to fabricate biodegradable vascular membranes\/grafts to enhance biocompatibility, extensive investigation is still required to develop new generation vascular membranes\/grafts that can match the compliance of native vascular tissues.<\/p>\n<div style=\"text-align: justify\">\n<p>In our team\u2019s research exploration, biodegradable polyurethane (PU) has been blended with elastin and chitosan nanoparticles as an initiative of vascular membrane development to overcome the limitations of non-biodegradable and thrombus generation following vascular surgery. This formulation is called ChitoE, which uses electrospinning to form polymeric mesh nanofibers.<\/p>\n<p>Electrospinning can create fibres with diameters ranging from micro to nanometer with a structure that resembles the extracellular matrix (ECM) of native small-diameter blood vessels. The structural electrospun elastomeric fibre networks allow the scaffolds to possess high surface-to-volume ratios and porosities that expedite cell attachment and ingrowth.<\/p>\n<p>It involves the application of an electric field on the polymer solution to produce nanofibrous polymer scaffolds. The device setup includes a syringe consisting of polymer solution mounted on the syringe pump and connected with the high applied voltage. The ejected nanofibrous material can be collected using a rotating collector to create tubular scaffolds or a flat collector to form thin film membranes.<\/p>\n<div>\n<p>This project collaborates with the National Heart Institute (IJN Sdn. Bhd.) to respond to the current clinical complication of vascular membranes and grafts at IJN. Dr. Sivakumar Sivalingam, the IJN cardiothoracic surgeon, who is a part of the team members, actively participated in lending clinical guidance during the development progress of the ChitoE product. The ChitoE is currently at TRL 4 for the in-vivo implantation for its physiological verification. It has been proven biodegradable, biocompatible, anti-thrombogenic and thermally stable.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div><div class=\"et_d4_element et_pb_row et_pb_row_1  et_pb_css_mix_blend_mode et_block_row\">\n\t\t\t\t<div class=\"et_d4_element et_pb_column_1_2 et_pb_column et_pb_column_1  et_pb_css_mix_blend_mode et_block_column\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_image et_pb_image_0\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<span class=\"et_pb_image_wrap \"><img loading=\"lazy\" decoding=\"async\" width=\"469\" height=\"243\" src=\"https:\/\/research.utm.my\/ihumen\/wp-content\/uploads\/sites\/85\/2023\/10\/ChitoE-Graft-2-e1696749671511.jpg\" alt=\"\" title=\"ChitoE Graft 2\" class=\"wp-image-13889\" \/><\/span>\n\t\t\t<\/div>\n\t\t\t<\/div><div class=\"et_d4_element et_pb_column_1_2 et_pb_column et_pb_column_2  et_pb_css_mix_blend_mode et-last-child et_block_column\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_image et_pb_image_1\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<span class=\"et_pb_image_wrap \"><img loading=\"lazy\" decoding=\"async\" width=\"677\" height=\"382\" src=\"https:\/\/research.utm.my\/ihumen\/wp-content\/uploads\/sites\/85\/2023\/10\/ChitoE-Graft-3.jpg\" alt=\"\" title=\"ChitoE Graft 3\" class=\"wp-image-13891\" \/><\/span>\n\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":11576,"featured_media":13892,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p><span class=\"OYPEnA text-decoration-none text-strikethrough-none\">A newly biocompatible, anti-thrombogenic<\/span> <span class=\"OYPEnA text-decoration-none text-strikethrough-none\">vascular membrane<\/span><\/p><div><p>Cardiovascular diseases have been the leading cause of mortality, according to the World Health Organization (WHO) for the past few years. In 2021, specifically in Malaysia the Department of Statistics recorded that 17% of Malaysians died due to ischemic heart disease as the topmost ranking, Followed by pneumonia (11.4%), cerebrovascular diseases (8.3%) and transport accidents (2.9%).<\/p><div><p>Most cardiovascular diseases require vascular reconstructive surgery to remove affected tissue lesions. Several vascular membranes\/grafts are commercially available to replace defective tissues in vascular reconstructive surgery. However, synthetic commercialized vascular membranes\/grafts known as GORE-TEX\u00ae (made of polytetrafluoroethylene (PTFE)) and Dacron\u00ae (made of polyethene terephthalate (PET)) are not biodegradable.<\/p><p>They are reported with post-complication of thrombotic formation following the implantation procedure. Although myriad tissue engineering approaches have been considered to fabricate biodegradable vascular membranes\/grafts to enhance biocompatibility, extensive investigation is still required to develop new generation vascular membranes\/grafts that can match the compliance of native vascular tissues.<\/p><div><p>In our team\u2019s research exploration, biodegradable polyurethane (PU) has been blended with elastin and chitosan nanoparticles as an initiative of vascular membrane development to overcome the limitations of non-biodegradable and thrombus generation following vascular surgery. This formulation is called ChitoE, which uses electrospinning to form polymeric mesh nanofibers.<\/p><p>Electrospinning can create fibres with diameters ranging from micro to nanometer with a structure that resembles the extracellular matrix (ECM) of native small-diameter blood vessels. The structural electrospun elastomeric fibre networks allow the scaffolds to possess high surface-to-volume ratios and porosities that expedite cell attachment and ingrowth.<\/p><p>\u00a0<\/p><div><p>It involves the application of an electric field on the polymer solution to produce nanofibrous polymer scaffolds. The device setup includes a syringe consisting of polymer solution mounted on the syringe pump and connected with the high applied voltage. The ejected nanofibrous material can be collected using a rotating collector to create tubular scaffolds or a flat collector to form thin film membranes.<\/p><p>This project collaborates with the National Heart Institute (IJN Sdn. Bhd.) to respond to the current clinical complication of vascular membranes and grafts at IJN. Dr. Sivakumar Sivalingam, the IJN cardiothoracic surgeon, who is a part of the team members, actively participated in lending clinical guidance during the development progress of the ChitoE product. The ChitoE is currently at TRL 4 for the in-vivo implantation for its physiological verification. It has been proven biodegradable, biocompatible, anti-thrombogenic and thermally stable.<\/p><\/div><\/div><p><img class=\"aligncenter size-thumbnail wp-image-13892\" src=\"https:\/\/research.utm.my\/ihumen\/wp-content\/uploads\/sites\/85\/2023\/10\/ChitoE-Graft-4-150x150.jpg\" alt=\"\" width=\"150\" height=\"150\" \/><\/p><\/div><\/div>","_et_gb_content_width":"","footnotes":""},"categories":[121,172,65,4],"tags":[],"class_list":["post-13797","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bulletin","category-bulletin-issue-8","category-ihumen","category-news"],"_links":{"self":[{"href":"https:\/\/research.utm.my\/ihumen\/wp-json\/wp\/v2\/posts\/13797","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.utm.my\/ihumen\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/research.utm.my\/ihumen\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/research.utm.my\/ihumen\/wp-json\/wp\/v2\/users\/11576"}],"replies":[{"embeddable":true,"href":"https:\/\/research.utm.my\/ihumen\/wp-json\/wp\/v2\/comments?post=13797"}],"version-history":[{"count":9,"href":"https:\/\/research.utm.my\/ihumen\/wp-json\/wp\/v2\/posts\/13797\/revisions"}],"predecessor-version":[{"id":18492,"href":"https:\/\/research.utm.my\/ihumen\/wp-json\/wp\/v2\/posts\/13797\/revisions\/18492"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/research.utm.my\/ihumen\/wp-json\/wp\/v2\/media\/13892"}],"wp:attachment":[{"href":"https:\/\/research.utm.my\/ihumen\/wp-json\/wp\/v2\/media?parent=13797"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/research.utm.my\/ihumen\/wp-json\/wp\/v2\/categories?post=13797"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/research.utm.my\/ihumen\/wp-json\/wp\/v2\/tags?post=13797"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}