Sumarni Mansur, Mohd Hafiz Dzarfan Othman, Ahmad Fauzi Ismail, Siti Hamimah Sheikh Abdul Kadir, Pei Sean Goh, Hasrinah Hasbullah, Be Cheer Ng, Mohd Sohaimi Abdullah, Fatmawati Kamal, Muhammad Nidzhom Zainol Abidin, Retno Ariadi Lusiana
Polyurethane (PU) with three different functional groups: carboxyl, hydroxyl and sulphonyl group on its molecular structure were synthesised in this work. The synthesised material suppresses blood clotting and exhibits anticoagulant characteristics due to the presence of the important anionic groups. The synthesised PU was blended with polyethersulphone (PES) and fabricated into flat-sheet membrane to study the physico-chemical and biocompatibility properties of the PES membrane for blood purification application. PES-PU flat-sheet membranes were fabricated via the dry-wet phase separation technique. Different loading of PU (0, 1, 2, 3, 4, and 5%) blended with PES was studied and compared. Based on the in-vitro biocompatibility analysis of the membrane, it can be suggested that the membrane incorporated with PU has better anticoagulant properties compared to the pristine PES membrane.